Our research focuses on the establishment and maintenance of chronic infection by gamma-herpesviruses. All herpesviruses share the property of establishing life-long infection in their host. Notably, the gamma-herpesviruses are all associated with the development of lymphomas and other cancers, particularly in immune suppressed patients. As such, it is important to understand the basic strategies employed by this group of viruses to persist in the infected host. We now understand that these viruses encode multiple, distinct genetic programs that facilitate chronic infection. We have primarily focused on defining these genetic programs and understanding how they are regulated.