Studies in the molecular virology of viruses which are important to the poultry industry. To this end, the analysis of the function of viral proteins and regulatory elements are performed to gain more insight into the viral replicating machinery. Development of species independent ELISA systems for the detection of influenza antibodies.  Usage of next generation sequencing in combination with bioinformatics for the search of new viruses with the goal tp developing new vaccines.

My vision is to apply the knowledge obtained from research to the development of new, more efficacious, custom-made and cost effective vaccines for the poultry industry. In addition, development of diagnostic tools is an important part of my research to obtain a more comprehensive overview about the prevalence of influenza virus in wild animals (birds and mammals).

We developed tools for the investigation of interactions between cellular proteins and the viral replication machinery. We found interactions between cellular and viral proteins. Next we will investigate whether this can be used as an intervention strategy during the infection of the host. Species independent ELISA was used for investigation of sera of wild birds. We detected H5 influenza virus specific antibodies in a variety of wild birds.  This tool will now be used to obtain more epidemiological data for prevalence of H5 specific antibodies in wild animals and thus more knowledge about the ecology of the virus.  By the use of next generation sequencing in combination with bioinformatics, we have identified four new viruses and development vaccine candidates based on molecular  virological methods.  These candidates are in the experimental phase for efficacy testing.

The University of Georgia enabled me to combine my research interests with the needs of the poultry industry, and my research interests fit very well with the objectives of the UGA Poultry Diagnostic and Research Center. Also important were the ability to be near other research facilities dealing mainly with problems of poultry production, and the support of the Georgia Research Alliance.  Furthermore the possibility of collaborating with scientists from the CDC in Atlanta was very promising.