Spatial Biology and Integrated Genomics (SBIG) Shared Resource
University of Georgia
The Spatial Biology and Integrated Genomics (SBIG) Shared Resource at the University of Georgia School of Medicine provides researchers with unparalleled access to single-cell multiomics and high-plex spatial imaging capabilities.
The core provides an end-to-end multiomics pipeline, enabling researchers to map gene and protein expression from single-cell suspensions up to intact tissue with cellular and sub-cellular resolution.
Equipment in the core:
- BD Rhapsody™ HT Xpress System & Scanner: A high-throughput single-cell isolation and analysis platform utilizing microwell cartridge technology for parallel multiomic profiling of tens of thousands of single cells, complete with automated quality control and cell-counting visualization.
- RareCyte Orion™: High-throughput, single-round automated fluorescence imaging utilizing up to 20 channels for protein profiling of large patient cohorts.
- Bruker CosMx® Spatial Molecular Imager (SMI): High-sensitivity, single-cell multiomic analysis capable of mapping up to 18,000 mRNA transcripts and 64 proteins at subcellular resolution.
- Bruker GeoMx® Digital Spatial Profiler (DSP): Morphology-driven, highly reproducible profiling of distinct tissue compartments, detecting up to 1,200 proteins and 18,000 mRNA transcripts.
- Parhelia Spatial Station™: Fully automated, standardized fluidic processing to ensure reproducible sample preparation and protect precious tissue specimens.
- Indica Labs HALO®: Advanced image analysis suite featuring specialized spatial modules for cell proximity, neighborhood analysis, and quantitative metadata extraction.
Services Offered: Experimental design consults, single-cell partition and library preparation, automated sample processing, high-plex spatial transcriptomic and proteomic scanning, cloud-based data storage/access via OMERO plus™, pathology consultation and interpretation, and quantitative spatial/single-cell bioinformatics.
More about this core facility at UGA's website »
This core is open to investigators across the Georgia research ecosystem.
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