Emory Gnotobiotic Animal Core
Emory University
Contact: Rheinallt Jones, PhD
Phone: (404) 727-7231
The Emory Gnotobiotic Animal Core (EGAC) is a member of the Emory Integrated Core Facilities (EICF). This cutting-edge core facility offers investigators the opportunity to experimentally manipulate the microbiomes of mice in a controlled environment to gain insight into important biological mechanisms.
The Scientific Director of the EGAC is Rheinallt Jones, PhD from the Department of Pediatrics in the Emory University School of Medicine. EGAC operations are overseen by a team of highly skilled staff members including Caroline Addis, MSc and Amanda Metzger, BA, RALAT.
The EGAC has twenty 3-foot- wide rigid isolators (Parkbio), each with the capacity to house 16 mouse cages. EGAC has a breeding colony of C57BL/6 mice housed within these isolators which they supply to investigators within Emory and at other U.S. institutions.
Investigators can also rent an isolator to house a mouse strain of their choice in germ-free status. EGAC staff communicate with investigators to maintain their germ-free mouse colony
In addition, EGAC has two Tecniplast ISOcage P Bioexclusion systems. These are airtight individual mouse cages with high positive pressure that are specifically designed for cage-scale germ-free, gnotobiotic, and bioexclusion studies.
For gnotobiotic studies, EGAC works closely with investigators to colonize germ-free mice with a defined microbiome including:
- Mono-colonization with a single microbe
- Gnotobiotic colonization with a defined microbiome such as Altered Schaedler flora (ASF)
- Colonization of germ-free mice with a human microbiome to create Human Microbiome Associated (HMA) mice
More about this core facility at Emory University »
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